High-Dose Inactivated Influenza Vaccine Linked to Lower Rates of Hospitalization in HF
Patients with heart failure who receive a high-dose inactivated influenza vaccine have a decreased risk for hospitalization.
High-dose inactivated influenza vaccine (HD-IIV) is associated with reduced rates of hospitalizations related to laboratory-confirmed influenza, cardiorespiratory disease, cardiovascular (CV) disease, and heart failure (HF) in patients with HF.
- The study was conducted in Denmark during 3 consecutive influenza seasons, from 2022 to 2023 through 2024 to 2025.
- The trial included individuals aged 65 years and older who were randomly assigned 1:1 to receive HD-IIV or standard-dose inactivated influenza vaccine (SD-IIV).
The findings are from a prespecified exploratory analysis of the DANFLU-2 trial.
A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs Standard-Dose Quadrivalent Influenza Vaccine in Older Adults; ClinicalTrials.gov Identifier: NCT05517174
Author's summary: High-dose flu vaccine reduces hospitalization rates.
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