Caspase-9 as a Potential Target for Pulmonary Fibrosis Treatment
A preclinical study suggests that blocking caspase-9, an enzyme involved in cell death, may be a potential treatment target for pulmonary fibrosis.
Researchers found that caspase-9 was elevated in lung tissue from people with pulmonary fibrosis and in a mouse model of the disease, particularly in diseased areas.
- Caspase-9 promotes lung fibrosis by triggering apoptosis.
- Caspase-9 also activates beta-catenin signaling, contributing to lung fibrosis.
Blocking caspase-9 may halt or reverse tissue scarring in pulmonary fibrosis.
In the study, blocking caspase-9 activity reduced signs of cell death and lung fibrosis in a mouse model of pulmonary fibrosis.
Author's summary: Caspase-9 is a potential target for treating pulmonary fibrosis.
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